BACKGROUND: Coronary artery bypass surgery is considered as the gold standard treatment of unprotected left main coronary artery (ULMCA) disease. However, rapid advances in percutaneous intervention (PCI) have made ULM-PCI a viable alternative.
OBJECTIVE: To compare the incidence of major adverse cardiovascular & cerebrovascular events (MACCE) among diabetic and non-diabetic patients with significant left main coronary artery disease treated with PCI.
METHODS: Cross sectional analytical study of elective Left Main Registry patients at the CSMC who underwent ULM-PCI from January 2007 to July 2014. Pearson's Chi-square was used to determine significant association between categorical variables.
RESULTS: There were 106 subjects (80% males) and ages ranged from 42 to 89 years old with a mean age of 65 years. The mean and longest follow-up was 4 and 7 years respectively. On follow-up, total MACCE was 13.2% (n=13) in diabetic and 5.7% (n=6) in non-diabetic based on p-0.1274. The total deaths between diabetic (n=6, 5.7%) was not significantly different from the non-diabetics (n=4, 3.8%) based on p-1.000. The proportion of revascularization between diabetics (n=7, 7.6%) is not significantly different from the non-diabetics (n=2, 1.9%) based on p-0.1084.There was also no significant difference in the incidence of stroke and myocardial infarction.
CONCLUSION: For patients with significant left main coronary artery disease, there was no significant difference between diabetic and non-diabetic patients with respect to major adverse cardiovascular and cerebrovascular diseases, total deaths, stroke, myocardial infarction and revascularization.